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To assess the systemic effects of biocide exposure, MOEs (margins of exposure), i.e. the ratio of NOAEL (No Observed Adverse Effect Level) and exposure concentration (as body dose), were calculated.
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The primary operator's whole-body dose was calculated according to the formula: Although this methodology leads to an overestimation of up to 100%, it can be considered representative of the amount of energy imparted to the physician.
For patients with a body mass index ≥30 kg/m2, the dose was calculated using the adjusted body weight, which was calculated as follows: ideal body weight (height (cm) − 100 − [height (cm) − 150]/4 for male gender and height (cm) − 100 − [height (cm) − 150]/2 for female gender) + 0.4 [total body weight at admission-ideal body weight].
Carboplatin dose was calculated according to the patient's body surface area (BS group), with the amount of carboplatin (mg) being set at 350 × body surface area (m).
The seizure threshold dose was calculated from the infused volume in relation to body weight [20].
Recombinant FSH starting dose was calculated taking into account the patient's age, body max index, AFC, and AMH values of the patients.
The exact AMPT dose was calculated on a per weight basis (40 mg/ kg body weight).
Indisulam dosing was based on body surface area and carboplatin doses were calculated with the Calvert formula to produce an area under the concentration time curve (AUC) of 5 or 6 mg min ml−1 (Calvert et al, 1989; van Kesteren et al, 2002).
The daily phenprocoumon dose was calculated by the weekly phenprocoumon dose before blood collection divided by 7. The body mass index (BMI) was calculated from each patient's self-reported height and weight (kg/m).
The PCC dose was calculated from the Quick value using the formula: target Quick value - actual Quick value × body weight (kg) = dose in IU.
Doses were calculated based on body surface area calculations or weight and were modified at each visit.
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