Sentence examples for blunted the development of from inspiring English sources

Chop overexpression or activation of amino acid starvation signals blunted the development of Th17 populaTh17s50,59.

Ezetimibe blunted the development of NASH in this model, suggesting its potential clinical usefulness for human steatohepatitis.

Evidently, the peripheral inflammatory lesions non-specifically attracted Teffectors that blunted the development of EAE.

We, and others, found that deletion of E2A in Id3−/− mice blunted the development of activated γδ T cells indicating that elevated E2A function is critical for development of these cells [35].

Treatment with anti-HMGB1 antibody significantly blunted the development of hyperpermeability [ 33].

Interestingly, rats given DPCPX at 1.5 h did not develop mesenteric vasodilatation across the 2- to 6-h period following LPS treatment (Table 1), suggesting that the earlier A1 receptor antagonism blunted the development of the hyperdynamic circulation.

The present study demonstrates for the first time that zelandopam, a selective dopamine D1-like receptor agonist, is effective in blunting the development of PA-induced nephrosis, and that the effects of zelandopam are dose dependent.

Fasudil and simvastatin treatment did not affect survival or lesion development significantly in Ccm2+/-Trp53-/ mice alone, and Fasudil benefit seemed limited to males.ROCK inhibitor Fasudil was more efficacious than simvastatin in improving survival and blunting the development of mature CCM lesions.

Notably, this anti-inflammatory effect of PPARγ ligands extends to the inhibition of IL-1β-induced expression of MMP-1 and MMP-13 in rabbit chondrocytes [ 2, 17, 18], and administration of these compounds blunts the development of joint disease in animal models of arthritis [ 18, 19].

Therefore, an alternative interpretation of the increased serum VEGF levels in patients with SSc and sPAP ≥ 35 mmHg, could be that the elevation of sPAP might by itself be the cause of the induction of VEGF synthesis and release from the pulmonary vasculature, in an attempt to blunt the development of vascular remodelling in the pulmonary vessels[ 33].

Using two diverse hypertrophic perturbations, we demonstrated that constitutive LXRα activation countervailed pathological growth and remodeling processes in the heart, including blunting the development of myocardial fibrosis, an observation in line with previous studies demonstrating the anti-fibrotic effects of LXRs in kidney (Tachibana et al, 2012) and in liver (Beaven et al, 2011).