Sentence examples for blunted responsiveness from inspiring English sources
MDD patients ascribe more negative emotion but also less positive emotion to facial expressions, suggesting blunted responsiveness to positive emotional stimuli.
As in our studies, gastric emptying was not found to be delayed in patients with type 1 diabetes under euglycemic conditions, but a blunted responsiveness to hyperglycemia was reported with a >50% reduction in the delay of gastric emptying in patients with type 1 diabetes.
While altered temperature responsiveness was more common than altered pain responsiveness across syndromes, blunted responsiveness to pain and temperature was particularly associated with behavioural variant frontotemporal dementia (40% of symptomatic cases) and heightened responsiveness with semantic dementia (73% of symptomatic cases) and Alzheimer's disease (78% of symptomatic cases).
This may be due to the blunted responsiveness of KATP channels to glucose stimulation in KO cells (Fig. 6).
For example, insufficient costimulation or other mechanisms may lead to anergy [ 20] or blunted responsiveness of tumor-specific effectors [ 21, 22].
This is exemplified by the accelerated aging-like phenotype of FGF-23 knockout mice [ 122] and by the decreased expression of FGF ligands and receptors (or at least blunted responsiveness to FGF signaling) in aged tissues such as brain, bone and skin [ 123- 127].
Thus it appears that diabetes preferentially blunts responsiveness to agonist-induced constriction in the conduit vessels.
Bedside experience and several clinical studies suggest that blunted cardiovascular responsiveness to catecholamine support is also a marker of high risk of death in sepsis and septic shock [ 13].
Other studies have also noted associations between decreased serum 25(OH D concentrations and decreased lung function, increased airway hyperresponsiveness to methacholine, and blunted glucocorticoid responsiveness.,, However, in a recent case-control study of obese subjects with and without asthma, no associations between vitamin D status and asthma prevalence were noted.
In light of the breadth of action of LPA, identification of ILMR, an agent that blunts responsiveness to LPA, is likely to guide development of therapeutic strategies to combat cancer and other angiogenesis-dependent pathologies.
During resuscitated murine septic shock, early ADM binding with HAM1101 improved catecholamine responsiveness, blunted the shock-related impairment of energy metabolism, reduced nitrosative stress, and attenuated systemic inflammatory response, which was ultimately associated with reduced kidney dysfunction and organ injury.
