Anesthesia concerns focus on the cardiovascular stability of patients who may be catecholamine-depleted and thus have a blunted response to intraoperative hypotension.
The authors concluded that those patients with eosinophilic esophagitis with identifiable allergies who failed dietary elimination may have a blunted response to treatment.
Aging, in the immune system, is characterized by a decreased ability to respond to exogenous insults, resulting in increased susceptibility to infections and blunted response to vaccination.
Within the social processes domain, preliminary evidence indicates that neural processing of social feedback, including heightened reactivity to exclusion and blunted response to social reward, may be related to depression vulnerability.
In tests of pain perception, rats in the control group displayed an analgesic response on the hot plate following an injection of the anxiogenic drug, RO 15-1788, wherats rats with centromedial lesions tended to exhibit a blunted response.
We have previously suggested that TTH patients have a reduced or "blunted" response to stress, evident by a lack of an initial "spiked" response and followed by a more or less constant HR throughout the stress period [32].
LPS administration resulted in a significantly blunted response of forearm vasculature to acetylcholine (P = 0.028, Figure 2A), whereas the response to nitroglycerine/nitroprusside was not significantly affected (P = 0.11, Figure 2B).
Strikingly, trsn does not appear to regulate energy stores, free glucose levels, or feeding behavior suggesting the sleep phenotype of trsn mutant flies is not a consequence of general metabolic dysfunction or blunted response to starvation.
The contribution of leptin resistance to obesity has also been established by the demonstration that hyperleptinemic animals and humans have a blunted response to exogenous leptin.
EBs generated from both of the Tim knockdown mES cell lines exhibited a markedly blunted response to staurosporine in terms of caspase activity as well as production of the cleaved, active form of Caspase 3 (Fig. 7).
Individuals heterozygous for these mutations have a blunted response to inhaled LPS [ 17].
