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We hope to unite the existing molecular and microscopic data on genome organization to get a holistic view of the nucleus, and propose a model, in which repeat repertoire together with scaffolding structures blueprint the functional nuclear architecture.
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Finally, the structural analyses provided here give the blueprint of the necessary functional properties of cellular counterparts operational in the topologically related transport of large ribonucleoprotein particles (RNPs) through the nuclear envelope (Speese et al., 2012), for which the search is still ongoing.
The human genome is the blueprint that encodes most of the functional components in the human body: proteins and RNAs.
Therefore, in the absence of a genome, we have used RNA-seq to sequence the transcriptome of bovine and feline T. foetus genotypes in an attempt to provide a blueprint of functional capacity of each of the host/niche adapted T. foetus genotypes.
These findings confirm the more accurate identification of molecular subgroups for treatment decision by the 80-gene BluePrint functional subtype classifier, which therefore may serve as a better guide for neoadjuvant treatment than standard, local IHC/FISH assay.
3 The objective of the current prospective NBRST study is to compare chemosensitivity as defined by pCR or endocrine sensitivity as defined by partial response (PR) for patients classified with the 80-gene BluePrint functional subtype profile to conventional IHC/FISH subtyping.
The functional and the dysfunctional.
Therefore with BluePrint functional subtype IHC/FISH HER2+/HR+ patients are subdivided into BPLuminal with a poor response to NCT/trastuzumab and BPHER2 with a good response to NCT/trastuzumab.
Our characterization of locally distinct patterns and dynamics of secondary neurogenesis in the entire early (2 dpf) postembryonic zebrafish brain delivers the blueprint for more specialized functional studies.
Is this the blueprint of the future?
This will rotate the blueprint on the ground by 90º.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com