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Manual or automatic blood sampling is generally accepted as the gold standard to determine the arterial input curve.
Arterial blood sampling is generally used in PET experiments to measure changes in the free fraction over time.
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Blood sampling was generally performed on admission (or upon confirmation of HIV status) for CD4 count or percentage measurement and every 6 months thereafter.
It is also difficult to relate the concentrations to the clinical picture because the interval between intake of the drug and drawing a blood sample is generally unknown.
Although whole-blood sampling is generally considered a more accurate measure in clinical pharmacokinetic studies of CQ, serum/plasma CQ concentrations may be more indicative of cell/tissue exposure levels and prove more meaningful in linking in vitro and in vivo findings.
Day 1 blood samples were generally drawn immediately following enrollment in the ED.
Of the patients who provided serial samples, the final blood sample was generally obtained from patients around the time of discharge, when they appeared to be in good health.
The blood samples were generally taken during the morning.
The blood samples were generally received by the NOWAC biobank staff within 1 2 days (92%).
Field blood samples were generally collected from the thoracic cavity of freshly killed raccoon dog.
To circumvent this problem, the blood samples are generally diluted with isotonic diluent before proceeding to benchtop separation process.
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