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Blood sampling for lysine acetylation, a biomarker of entinostat activity, takes place at cycle 1 day 1, and cycle 1 day 15.
Blood sampling for pharmacokinetic analyses is optional and takes place at cycle 1 day 1, cycle 1 day 15 and prior to cycle 2.
Control samples were obtained from fetuses who were undergoing blood sampling for clinical indications and had normal outcomes (n = 21).
Blood sampling for measurement of leptin, cortisol, glucose, and insulin was performed at baseline and every 1 to 2 hours.
Techniques applied for studying male reproductive physiology in these species are often invasive and stressful (i.e. repeated blood sampling for sexual steroids analysis).
Future work in the rodent model will incorporate arterial blood sampling for more accurate quantification.
Quantification of uptake may be improved by using blood sampling for plasma radioactivity assessment.
Fish were not fed during the 24 h immediately prior to blood sampling for all sampling dates.
The ARDS patients stayed longer in the ICU than the controls, allowing serial blood sampling for GILZ analysis.
(A) Seven-day mortality in 4-week-old 4-week-old 4-week-oldo CLP-Only and daily low-volumicelood subjectedfor days 1 to 5 post-CLP.
Another limitation was the absence of arterial blood sampling for blood and plasma activity and metabolite analysis, which could have provided a more accurate quantification of tracer uptake.
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