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Completion of the self-administered questionnaire and receipt of the blood sample were considered to imply informed consent.
Completion of the self-administered questionnaire and submission of a blood sample were considered to imply informed consent.
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Completion of the questionnaire and submission of the blood sample was considered to imply informed consent.
A blood sample was considered CTC-positive when at least five CTC were present based on the prognostic relevant cut-off as previously published [ 3, 6].
In the absence of difficult-to-obtain bone marrow specimens, microbiologic culture of a blood sample is considered to be the current state-of-the art test for the diagnosis of typhoid fever even though its sensitivity may be as low as 40% [ 4, 5].
Using the two cutoff values, 75.8% (50/66) and 45.5% (30/66) of B0 and B4w blood samples were considered MUC1 mRNA positivity; 71.2% (47/66) and 43.9% (29/66) of B0 and B4w blood samples were considered VEGF mRNA positivity, respectively.
All patients confirmed to carry anti-HCV by repeated tests on new blood samples were considered positive.
Patients with the same strain of Candida in peripheral and catheter blood samples were considered as being with CRCBSI, while patients with Candida-positive peripheral blood cultures only or different strains were considered as non-CRCBSI.
Persisting high titers (≥ 1/40) in the first and following blood samples were considered as a proxy for exposure to the same source as the case, while seroconversion was considered as a proxy for secondary transmission whereby the case acts as probable source for the control.
To assess the within-person test reproducibility of the continuous QFT results, only data from the initial testing of the blood samples was considered since in routine clinical or public health practice blood will not usually be stored and re-tested at a later date.
For these one-versus-all SVMs, whole blood samples are considered as negatives in a leukocyte classifier, for example.
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