The effects of i.v. bolus injections (0.03, 0.1, 0.3, 1 and 3 mg/kg) of isometheptene racemate, (S -isometheptene or (R)-iS -isomethepteneheart rate and blord pR -isometheptenelyzed in contR -isometheptene
The metabolic variables and blood pressure were analyzed by mixed-model (repeated measure two-factor) ANOVA.
Changes over time in HbA1c, FPG, and blood pressure were analyzed using restricted maximum likelihood based mixed model repeated measures.
Mean changes in office blood pressure were analyzed according to the grade of hypertension and pre-existing antihypertensive treatment (ACE inhibitor + HCTZ, ARB + HCTZ).
In addition, hemodynamic data, such as heart rate and blood pressure, were analyzed with repeated-measure analysis of variance (ANOVA) for intra- and intergroup comparisons.
The data on blood pressure were analyzed by one-way analysis of variance (ANOVA) with repeated measures, followed by Fisher's protected least squares difference (PLSD) test using Prism (Graph Pad Software Inc., San Diego, CA, USA).
For 24-h blood pressure data, daytime average, nighttime average, and 24-h average values for systolic blood pressure and diastolic blood pressure were analyzed using a PROC MIXED model with sequence, treatment, and period as fixed factors and subject (nested in sequence) as a random factor.
Blood pressure was analyzed as the mean of the three recorded systolic pressures.
The relationship between urinary arsenic and blood pressure was analyzed by the Pearson correlation and partial correlation analysis.
