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The heart TAC was utilized as the blood input function for fully quantitative kinetic modeling.
(A) Average blood input functions following [11C]acetate injection in normal control mice (n = 5).
The carotid artery STD and the inferior VC blood input curves are shown in Figure 2.
Whole blood input functions as well as regional TACs were derived as described above.
Figure 3 Representative blood input function (filled yellow squares) and tumor tissue tracer concentrations.
There were no significant differences in blood input areas-under-the-curve (AUCs) or MBFi values.
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In this model, a whole-blood input function is used instead of plasma sampling [ 26, 40].
Figure 3 Simultaneously estimated vs blood-sampled input functions: two and three blood samples.
Tissue proteins are in a dynamic equilibrium with proteins in the blood, with input from proteins in the diet and losses through urine, feces, and skin.
Finally, the plasma blood sampler input function (BSIF) CP t) was obtained by multiplying the delay- and dispersion-corrected and calibrated blood TAC with both these sigmoid functions.
Capilllary glucose values through self-monitoring of blood glucose SMBG were input twice a day for adjustment.
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