Sentence examples for blood gene expression changes from inspiring English sources

Systemic and local inflammation plays a prominent role in the pathogenesis of atherosclerotic coronary artery disease, but the relationship of whole blood gene expression changes with coronary disease remains unclear.

PTD is associated with maternal early pregnancy peripheral blood gene expression changes.

In summary, we have shown that PTD is associated with maternal early pregnancy blood gene expression changes.

However, it is known that, within minutes of collection, peripheral blood gene expression profiles change significantly due to transcript induction and transcript degradation[ 1], and it is almost certain that the purification process introduces further changes in expressed transcripts.

Activation of Nkx2.3 may indicate changes in levels of spleen growth and contribute to the changes in blood gene expression as a result of these changes.

This result emphasizes the limitations of peripheral blood studies in determining gene expression changes in diseased target tissues.> Pathways associated with dendritic cells and antigen presentation were significantly upregulated (Table  3).

To our knowledge, this is the largest study to date using whole peripheral blood to investigate early gene expression changes in drug-naïve and de novo sporadic PD patients.

In order to assess for an association between perioperative variations in white blood cell subpopulations and gene expression, changes in neutrophil, lymphocyte, monocyte and eosinophil counts over the initial 24 hours were compared with changes in individual gene expression over the same period (see Additional file 5).

The expression pattern of these 160 genes in aortic tissue also predicted the severity of atherosclerosis in human aortas, showing that peripheral blood gene expression associated with coronary atherosclerosis mirrors gene expression changes in atherosclerotic arteries.

Thus, even in this complicated period, by looking at the evolution of the changes in whole blood gene expression, we identified 2447 genes that change uniquely as a function of time and these mapped to 19 canonical functional pathways (Figure 3C).

Molecular biomarkers for ionizing radiation exposure (gene expression changes, blood proteins) can be measured in real time using such diagnostic detection technologies as miniaturized nucleic acid sequences and antigen-based biosensors, but they require validation of dose-dependent targets and development of optimized protocols and analysis systems.