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Results: Skin blood flux changes (mean±S.E.M).
Using repeated-measures analysis of variance (ANOVA), significant difference (P<.05) in skin blood flux changes were revealed between these three occlusion durations, where 3 min occlusion produced significantly greater in skin blood flux occlusion change compared to 1 and 2 min occlusion.
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The primary outcome calculated was maximal change in skin blood flux before and after occlusion, expressed in arbitrary units (AU).
To examine the predictive performance of IOMA, we applied it to predict metabolic flux for red blood cells (RBC) for which a detailed kinetic model is available for validation (utilizing it to simulate metabolic flux changes following gene knockouts based on artificially generated proteomic data).
Finally, the biofilm-associated reactions with large flux changes are identified from the flux-change curve).
Predicted intracellular flux changes were consistent with published measurements on intracellular metabolite levels and fluxes.
Assuming that the MUSIC power estimates blood flux, we can estimate total blood flux by integrating these values in a given region of interest.
The effect of minimizing the flux changes is especially pronounced in the two variants of the flux-based R-DFBA.
MOMA predicts the flux redistribution which has the smallest Euclidean distance to the wild type flux distribution obtained by FBA, while ROOM minimizes the number of (significant) flux changes from the wild type flux distribution.
We measured mean and standard deviation of total blood flux in Figs. 4A- 4L.
A previous study showed that low-level static contraction did increase trapezius muscle blood flux [ 9].
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