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Much less data are available from direct comparisons of brain and blood expression patterns.
Such regional specificity, however, is likely to predict lack of expression of transcripts in peripheral tissues and therefore the impossibility of using correlated brain and blood expression patterns to guide studies of such transcripts in peripheral blood.
If the ME of one module is highly correlated with that of another module in the blood data, then the genes inside the two modules have similar blood expression patterns, i.e. the two modules cannot be distinguished.
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Therefore, while a transcriptome analysis of isolated granulocyte fractions would be most desirable in future studies addressing associations between BMI and gene expression, whole-blood expression patterns are also of value but likely underestimate the true expression changes occurring in different white blood cell populations, including granulocytes.
We previously identified second-trimester amniotic fluid and term cord blood gene expression patterns suggesting dysregulated brain development in fetuses of obese compared with lean women.
Maternal early pregnancy blood gene expression patterns may be useful for better understanding of PTD pathophysiology and PTD risk prediction.
Our motivation for this exercise was to provide proof-of-concept data to test if blood gene expression patterns can have predictive value in the context of obesity.
Thus, our structural analyses confirmed that, in saliva, the blood group expression patterns are borne out at the oligosaccharide structural level.
Such studies have shown that, in both brain and blood samples, expression patterns distinguish between samples drawn from patients or control individuals.
Maternal early pregnancy peripheral blood gene expression patterns may be useful for better understanding of the pathophysiology of PTD and risk prediction.
Maternal early pregnancy peripheral blood gene expression patterns may be useful for better understanding of PTD pathophysiology and PTD risk prediction.
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