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Recent dose-finding studies at the University of Maastricht, which investigated the effect of 10 μg, 20 μg and 45 μg MK-7 daily on the anticoagulant properties of vitamin K antagonists, showed that even with a daily supplement of < 10 μg MK-7, a significant disturbance of blood coagulation control can occur.
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Among these applications, strong interest has been shown to biological processes such as blood coagulation control and multimodal bioimaging, which has brought about a new and exciting research field called nanobiotechnology.
Changes in the blood coagulation cascade can also contribute to microthrombi formation [ 40].
The process of blood coagulation activation can be divided into several stages.
Collagen-based hemostats offer native tissue scaffolds for blood coagulation and can potentially act as biomimetic nanofibrous templates for instructional tissue regrowth.
They may be generated in the tumor microenvironment independently of blood coagulation and can induce cell signaling through activation of protease-activated receptors (PARs).
The extent of the stimulation of blood coagulation can be determined by assaying the generation of kallikrein, a serine protease.
Fibrin, the end product of blood coagulation, can be converted into soluble fragments (fibrinolysis).
The activation of blood coagulation can be caused by trauma, sepsis, inflammation, obstetric practice and in the course of surgical operations, especially operations using extracorporal blood circulation.
Thrombogenicity of nanoparticles is the outcome of interactions between nanoparticles and blood coagulation components and can induce blood clotting and partial or complete occlusion of blood vessels.
Heparin is the most widely used pharmaceutical to control blood coagulation in modern medicine.
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