In vivo and ex vivo distribution studies demonstrated RVG29-lip selectively distributed to the brain, striatum and substantia nigra.
Concentration time profiles of acetaminophen were obtained by microdialysis at different sites in the brain (striatum, lateral ventricle, and cisterna magna), and by serial parallel blood sampling, plasma kinetics were obtained.
Experiments in rats were performed using intravenous drug administration and concurrent sampling of blood and collection of microdialysis fluid from probes located in brain striatum ECF, lateral ventricle CSF, and cisterna magna CSF.
IHC stained cultures of rat brain striatum, exposed to P25 (5 ppm) were photographed and analyzed morphometrically.
Brain stem, olfactory lobe, mid-brain, cerebellum, striatum and cortical regions were dissected from control adult mouse brains (C57BL/6 strain).
The team found that the "go-getters" had higher levels of dopamine in the reward and motivation portions of the brain - the striatum and ventromedial prefrontal cortex.
"This sickening smell of blood, smashed brains, guts, and blood, blood, everywhere.
MCAO results in infarcts and neuronal death in large regions of the brain including the striatum and cortex.
Trunk blood and brain tissues from the hippocampus, striatum, and sensorimotor cortex were collected.
Dopaminergic structures within the brain, such as the striatum and nucleus accumbens, have also been implicated in reward-related behaviour.
