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Figure 6 Bias due to interpretation of blood activity.
Great saphenous vein blood activity exhibited similar patterns for intradermal and subcutaneous depots.
The image-derived blood activity (dashed line) was taken from the iliac and femoral vessels.
Blood activity was lower for the 177Lu-complex, but renal clearance time showed to be longer.
The activity of a reference TAC devoid of tracer trapping replaced the blood activity.
Moreover, patients on therapy had higher blood activity concentrations, normalized to injected dose and patient weight.
The blood activity was low even from 6.5 to 11 min, suggesting rapid blood clearance.
Brain time activity curves (TACs) were corrected for the contribution of blood activity assuming a 5% blood volume.
For this purpose, a new automated tool for the determination of blood activity as a function of time is presented.
Blood activity increased faster and to a greater extent in the great saphenous veins compared to the medial cubital vein.
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Blood-plasma partitioning and metabolite corrections were applied to the whole-blood activity curve to calculate the plasma concentration for the active tracer.
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