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Linkage disequilibrium (LD) between marker loci was assessed and haplotype blocks were constructed using Haploview 4.1.
Haplotype blocks were constructed using the LD block parameters [73], and the D' confidence interval algorithm in the Haploview program.
Briefly, tissue blocks were constructed using archival formalin-fixed, paraffin-embedded radical prostatectomy specimens from the 82 patients with pathological state of pT3a or b and pre-operative PSA stage of >3.
Tissue microarray blocks were constructed using an automated tissue microarrayer (TMA Master, 3DHistech, Budapest, Hungary).
Tissue blocks were constructed using a tissue array (Minicore; Alphelys Impasse Paul Langevin, Plaisir, France).
TMA blocks were constructed using the TMA-builder from Histopathology Ltd. (AH-diagnostics, Denmark).
Similar(45)
The effectiveness of the PMCM lower bound is demonstrated by examples, where pipelined shift-and-add multiple constant multiplication blocks are constructed using the algorithms from [7, 8, 22, 30] and [36] for the case of 2-input additions and the algorithm from [10] for the case of 3-input additions.
The TMA block was constructed using a Manual Tissue Arrayer 1 (Beecher Instruments, Silver Spring, MD, USA) with a 1.0-mm diameter core biopsy needle.
Haplotype blocks (bins) were constructed using LDselect (Christopher S. Carlson and Deborah A. Nickerson, Seattle, Washington, USA), a software package that provides computation of linkage disequilibrium (LD) statistics and population haplotype patterns from genotype data [ 45].
Based on the LD, 2 block haplotypes were constructed using Haploview version 4.2.
The haplotype blocks in the significant region were constructed using Haploview [ 22] to examine the LD in the region and among significant DArT-seq markers.
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