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Size estimates of blocks were calculated using ArcGIS and verified by comparing to published accounts in government sources.
Haplotype blocks were calculated using Haploview [ 34].
Haplotype blocks were calculated using Haploview 3.2 software [ 25].
Differences in age and RIN-scores of the tissue blocks were calculated using a t-test and a Mann–Whitney test.
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The SAD costs for the 4 x 4 blocks are calculated using Equation (2) [29].
Summary volumes for each block were calculated using SPM2 (Wellcome Department of Imaging Neuroscience, London, UK; http://www.fil.ion.ucl.ac.uk/spm) by fitting a GLM with separate parameter estimates for each block.
The standard deviations of K s for a syntenic block were calculated using in-house scripts with the equation below where x i is K s for individual gene pairs in a syntenic block and is average Ks for a syntenic block.
For example, the conductivity of the bold block is calculated using Eq. (2) and is estimated to be σ h.
The minimum time-of-flight (Datta-Gupta and King 1995) from each well to each block is calculated using Dijkstra's algorithm diffusing and updating the time-of-flight iteratively (Hetland 2014).
The LD block was calculated using Haploview 4.2 [ 47].
The low p-value of rs12959910 was not replicated in the G-EAR cohort (p = 0.11).> -wrap-foot> LD block refers to the numbered LD blocks that were calculated using a solid spine of LD in Haploview.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com