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A drug approved for melanoma blocks the function of that gene product, but it has not worked in colon cancer patients.
But these colon cancer patients often have an additional genetic aberration that can be attacked with a different drug, one that blocks the function of a cell protein, EGFR.
Leonard Zon said his group is waiting for FDA approval of a drug that blocks the function of the gene BRAF, which has long been known as a melanoma promoter.
Therefore miR-294/302 family blocks the function of let-7 at multiple levels.
Normal cellular and whole heart function was restored in MLP mice that express a cardiac-targeted transgene, which blocks the function of beta-adrenergic receptor (beta-AR) kinase-1 (betaARK1).
Cyclopamine, it turns out, blocks the function of a gene called Sonic hedgehog that is essential for embryonic development but also plays a lead role in causing deadly cancers of the pancreas, skin, prostate and esophagus.
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The new therapy is an antibody that blocks the functioning of a molecule called GD2 on the surface of neuroblastoma cells.
At Downstate, the researchers found a chemical that blocks the functioning of a molecule that is apparently used to retain information.
In addition, functionalized nanoparticles themselves or their metabolites can also block the function of ABC transporters such as P-gp by direct or indirect interaction and inhibition.
Indeed, drugs that specifically block the function of the mutated EZH2 protein are in development.
Researchers gave each monkey a local anesthetic to temporarily block the function of the flexor nerves in its arm.
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