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We found that compound 8a significantly blocks the adhesion of neutrophils to endothelial monolayer.
MAb 107 is a ligand mimic of CR3 that blocks the adhesion of leukocyte and their transendothelial migration (diapedesis), a feature that confers this MAb a potential anti inflammatory activity.
To our knowledge, however, our report is the first to show that LL-37 blocks the adhesion of a fungal pathogen to substrates.
We have recently demonstrated that the pool of sulfated polysaccharides from L. saccharina efficiently blocks the adhesion of a highly metastatic tumor cell line to human platelets [2], suggesting that this compound could also be a promising inhibitor of one of the earliest processes favouring tumor metastasis [22].
These authors also observed that salmosin inhibits the adhesion process via two possible mechanisms: (i) it specifically blocks the adhesion of cells to the ECM, via αv β3 or β1 or (ii) via induction of apoptosis, also blocking the αv receptor.
BaG also blocks the adhesion of K562 cells to fibronectin (and detaches cells previously adhered to this protein), a phenomenon mediated by binding to α5β1 integrin, but has no effect on the adhesion of these cells to collagen type I (mediated by α2β1 integrin).
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Soluble carbohydrates recognized by the bacterial surface lectins block the adhesion of the bacteria to animal cells in vitro.
Jerdostatin selectively blocked the adhesion of α1β1-K562 cell to collagens I and IV in vitro and angiogenesis in vivo.
The competition between nano-topography and a controlled dosage of drugs may either accelerate or block the adhesion of cells on a nanostructured surface, for applications in tissue engineering, regenerative medicine, personalized lab-on-a-chips, and the rational design of implantable drug delivery systems.
The contact angle variation after the surface soaked in protein solution indicates that the fabricated biomimetic surface microstructure can block the adhesion of protein.
It has been shown that EGCG binds to the intercellular adhesion molecule 1 (ICAM 1) on the endothelium thus blocking the adhesion of Plasmodium infected erythrocytes [20].
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