At 100 μM of DMNB-PA, we observed a fivefold reduction in protein levels, indicating that the caged ligand blocks the activity of the active, uncaged form in vivo.
Cl-amidine functions as a "pan-PADI" inhibitor as it blocks the activity of all active PADI family members (i.e. PADIs 1 4) with varying degrees of specificity [ 41].
It is known that the immunosuppressive drug Cyclosporin A (CsA) blocks the activity of the Ser/Thr phosphatase calcineurin and thereby the activation of the transcription factor NFAT.
As Akt blocks the activity of pro-apoptotic proteins and also cross-activates other survival pathways, its inhibition by 5c represents an effective mechanism for inducing cell death in colon cancer cells.
Gleevec blocks the activity of BCR-ABL by sitting in the enzyme's active site.
Cyclosporine A, a cyclic oligopeptide macrolide, blocks the activity of cytoplasmic calcineurin phosphatase thereby specifically inhibiting cytokine induced activation of cells that initiate the cutaneous immune response and mediate allergic reactions.
The major active compound in A. paniculata extracts is andrographolide, which blocks the activity of NF-κB, known to be the central transcriptional factor of genes involved in immunologic responses [ 30, 31 ].
Arginase blocks the activity of a chemical called arginine that is crucial for making nitric oxide.
The antibody blocks the activity of a chemical released after spinal cord injury that blocks nerve growth.
Iressa blocks the activity of a different tyrosine kinase, called EGFR.
Cyanide, however, is a dangerous poison that blocks the activity of an enzyme that is directly involved in oxygen uptake during respiration, resulting in cyanosis and asphyxiation.
