Sentence examples for blocks the activation of from inspiring English sources

For example, the inhibition of PI3K activity blocks the activation of PAK1 and cell migration in response to heregulin [46].

To be noted, in addition to FAK kinase activity, this compound also blocks the activation of poly (ADP-ribose) polymerase and caspase-3.

This effect is prevented by gefitinib, which blocks the activation of EGFR, ErbB2, stimulation of mitogen-activated protein kinase (MAPK), cell proliferation induced by EGF.

It is also evident that Smad7 blocks the activation of R-Smads, and/or competes with activated R-Smads for heteromeric complex formation with Smad4 [27], [27], abrogating cardiac differentiation in pluripotent cells [23].

This is in agreement with previous investigations from our laboratory and from others which have shown that curcumin blocks the activation of NF-κB and exhibits synergistic activity with 5-FU against tumor cells [ 26, 30, 59- 61].

More recently bcl-2 has subsequently been discovered to bind to, and suppress activation of the NLRP1 inflammasome, inhibiting release of IL-1 β in response to the NLRP1-activating ligand muramyl dipeptide, and also blocks the activation of the NLRP3 inflammasome in response to apoptotic stimuli in mouse macrophages.

CHS-111 was subsequently found to reduce levels of active GTP-bound RhoA by blocking the activation of the RhoA-specific GEF Vav.

In addition, the active constituent of DWYG, such as curcumin, has already been reported to block the activation of Hh signaling pathway through inhibiting Shh expression [ 14].

We suggest that Bcl-2 may block the activation of the caspase cascade and protect CV1-P cells from apoptosis.

Blocking the activation of DMH neurons pharmacologically interrupts the stimulation of brown fat thermogenesis [31], [32].

Moreover, suppression of APJ with siRNA blocked the activation of ERK and Akt (Fig. 4C).