Sentence examples for blocks of sequence conservation from inspiring English sources
Using computational genomics, we identified four putative CRMs within this region, similar to the blocks of sequence conservation discovered by Miller et al. (2007), that are conserved in position and sequence between mouse and fugu (fig. 1 A).
The existence of blocks of sequence conservation may however not be necessary for the conservation of enhancer activity [7].
However, they also occur in larger blocks of sequence conservation, suggesting an active role for the neighbouring amino acids.
For example, comparisons of the D. melanogaster apterous locus with its orthologs in three other Drosophila species revealed several isolated blocks of sequence conservation, at least one of which corresponds to a transcriptional enhancer [16].
To accomplish this, each genome is indexed three independent ways, each staggered differently; additionally, the alignment parameters have been adjusted to enhance the detection of short blocks of sequence conservation.
EvoPrinterHD advances the EvoPrint method by providing an automated higher-definition view of sequence conservation from which the conserved sequence blocks can be rapidly curated for subsequent analysis.
DBL2X polymorphism consists of defined blocks of variability, divided by regions of sequence conservation, a pattern of variation generally observed in PfEMP1 protein domains [14] [16].
Analysis of sequence conservation identified 354 elements that are conserved.
NAS of the first sequence in each block was used as one of the features for evaluation of sequence conservation, and it also served as an indicator of evolving rate for a protein during evolutionary courses.
Here we report a novel algorithm that features two innovative changes: 1. making better use of sequence conservation information by grouping the homologous protein sequences into six blocks according to evolutionary distances to human and evaluating sequence conservation in each block independently, and 2. including as many such homologous sequences as possible in analyses.
The high level of sequence conservation was illustrated both by the identical order of microsyntenic blocks in soybean chromosomes and by their concerted orientation.
