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A randomization list was generated by computer in random blocks of five patients, and blinded for the investigators.
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They were randomly divided into two equal groups using the computer-generated random permuted blocks of four patients.
All 40 patients were selected by convenience sampling, and further randomization into two groups was carried out by using the computer-generated random permuted blocks of four patients.
The random allocation sequences were in blocks of ten patients conducted using computer-generated lists administered by a colleague from DHC not involved in the study.
GlaxoSmithKline generated the randomization schedule comprising blocks of six patients by center.
Block randomization with blocks of four patients will be carried out centrally in the University Pharmacy Greifswald.
A computer-generated randomised list was used to provide balanced blocks of four patients each.
Randomization will be performed using a computer generated sequence in blocks of four patients.
Each dose was tested in blocks of ten patients starting with 20 mg.
The allocation will be based on computer randomization in blocks of four patients.
Subjects were divided randomly into two groups, a control group and an intervention group, using the block randomisation technique (blocks of four patients).
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