Sentence examples for blocks cell cycle progression from inspiring English sources

As shown in the present study HNF6 is detrimental to malignantly transformed cells and blocks cell cycle progression.

This membrane-associated cytoplasmic phosphoprotein blocks cell cycle progression from the G0/G1 to the S-phase [146] and therefore plays a role in cell cycle progression.

It has been reported that the expression of a dominant negative NF-Y mutant blocks cell cycle progression in G1 and G2 [37], [37].

For instance, ATM/ATR kinases can activate the tumor suppressor protein p53 that in turn either blocks cell cycle progression or induces apoptosis through regulation of the Bcl-2 family of proteins [37], [38].

In breast cancer cells miR-27a acts as an oncogene by targeting Myt-1, which blocks cell cycle progression at G2-M and through regulation of Sp proteins that have an important role in angiogenesis and growth of cancer cells [36].

UCN-01 also blocks cell cycle progression and promotes apoptosis.

The microtubule targeting compounds engage at the mitotic spindle checkpoint where they block cell cycle progression at mitosis ultimately leading to apoptosis (Bhat and Setaluri [2007]).

Checkpoint kinase 1 (ChK1) is activated in response to DNA damage, acting to temporarily block cell cycle progression and allow for DNA repair.

At the concentration that can block cell cycle progression and DNA synthesis but not elicit apoptosis, these inhibitors potentiate FasL to induce apoptosis.

The use of antimitotic substances, such as colchicine, promotes depolymerization of microtubules and prevents the formation of spindle fibers, this methodology is used to block cell cycle progression and thus induce polyploidy (Pereira et al. [2012]).

Therefore, it was concluded that L-4 can inhibit the proliferation of EC109 cells via blocking cell cycle progression and inducing reactive oxygen species-dependent and mitochondria-mediated apoptosis.