Sentence examples for blocks by activating a from inspiring English sources

By analyzing tumor biopsies from patients who relapsed on vemurafenib, researchers are learning how tumors become resistant: Often they restore the growth pathway that the drug blocks by activating a protein further downstream called MEK.

The model also simulated the therapeutic administration of anti-CD8 antibodies; this intervention was assumed to activate T-cell production by activating a feedback mechanism blocked by the high numbers of CD8 + lymphocytes present in HIV-infected persons.

Vaccines work by activating a patient's immune system.

Proliferation of bone marrow-derived stem cells is blocked by activating the cell cycle inhibitors p53 and p21.

6, 7 Hotta et al reported that intermittent occlusion of a unilateral common carotid artery in rats decreased blood flow by 13%32%%, but that the decrease in blood pressure was almost completely blocked by activating vasodilator nerves originating in the nucleus basalis of Meynert.

Alternatively, CO has been shown to block apoptosis by activating NF-κB [23], [24].

Thus, it is possible that TP53 is activated following expression of reprogramming factors by DNA damage, and that oncogenes block reprogramming by activating DNA damage responses.

Evidence for the cytoprotective role of TLR5 comes from studies showing that TLR5 ligation can block apoptosis by activating downstream antiapoptotic genes [22].

This suggests that DSBs in the cdc6-mn strain inhibit DNA replication, possibly by directly blocking replication forks and/or activating a DNA damage checkpoint.

This striking difference can be explained, at least in part, by the specific capacity of iPTH to increase T cell production of Wnt10b [19], a Wnt ligand that stimulates osteoblastogenesis and blocks OB apoptosis by activating Wnt signaling in OBs [36].

CXCL5 blocks insulin signaling by activating the Jak2/STAT5/SOCS2 pathway.