Sentence examples for blocks activation of the from inspiring English sources
Studies in both Drosophila and vertebrates have shown that the o-fucosyltransferase activity of Fng proteins leads to a modification in Notch receptors that blocks activation of the pathway by the Serrate/Jagged class of ligands [37].
NLRC3 associates with PI3Ks and blocks activation of the PI3K-dependent kinase AKT following binding of growth factor receptors or Toll-like receptor 4. These findings reveal a key role for NLRC3 as an inhibitor of the mTOR pathways, mediating protection against colorectal cancer.
An intriguing possibility is that BAY 11-7082 also blocks activation of the inflammasome by targeting components of the ubiquitin system that affect the NALP3 ATPase.
Next, we transiently transfected J774 cells with a IκBα-AA plasmid, a dominant-negative mutant of IκBα that blocks activation of the canonical NF-κB.
For example, modification of IκB kinase by the reactive electrophiles Δ-15-deoxy-PGJ2, 4-hydroxynonenal (HNE), or parthenolide blocks activation of the NF-κB signaling pathway.
Second, overexpression of I κB α-SR blocks activation of the non-canonical NF- κB pathway and suppresses BV6-stimulated cell elongation, migration and invasion.
To date, no compounds have become available that specifically activate, or block activation of, the stress protein response.
Knockdown of DDX41 expression blocked activation of the mitogen-activated protein kinase TBK1 (TANK-binding kinase 1) and the transcription factors NF-κB and IRF3 (interferon regulatory factor) by B-form DNA but not RNA.
Molecular studies showed that silk proteins suppressed the expression of Notch-activated genes and blocked activation of the Notch-specific reporter.
