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Scientists found that blocking the synthesis of one of the proteins involved in mediating this adherence process renders the parasite susceptible to elimination by the host's immune system.
In cutaneous T-cell lymphoma (CTCL), MTX increases Fas death receptor by decreasing Fas promoter methylation by blocking the synthesis of SAM, the principal methyl donor for DNMTs, resulting in enhanced Fas-mediated apoptosis.
The azole antifungal agents, which are further divided into the imidazoles and triazoles, according to the number of nitrogen molecules in their organic ring structure, exert their effects by binding to fungal membranes and blocking the synthesis of fungal lipids, especially ergosterol.
In comparison, IL-10 is an anti-inflammatory cytokine responsible for blocking the synthesis of pro-inflammatory cytokines and negatively regulates NFκB activation.
Triclosan works specifically by inhibiting the active site of the enoyl-acyl carrier protein reductase enzyme (ENR) which is an essential enzyme in fatty acid synthesis required for building cell membranes and lipid production in the microbe by blocking the synthesis of lipids (Annis 2012; Dorugade and Bhagyashri 2010; Gao and Cranston 2008; Purvar and Joshi 2004).
The apparent lack of a transaldolase homolog in the PPP may have effects on the organisms' ability to respond to oxidative damage (discussed above), but may also limit an alternative mode for ATP production via glycolysis by blocking the synthesis of F6P and GAP.
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They either block the synthesis of cholesterol within the bodies' cells or they prevent cholesterol uptake in the intestine, forcing ingested cholesterol to pass through the body and never be absorbed.
By the early 1970s it was already recognized that mimicking folic acid was a powerful way to block the synthesis of DNA/RNA, which in turn stops cells from dividing – a good thing in, say, cancer.
Since aromatase inhibitors (AI) block the synthesis of estrogen and have no intrinsic estrogenic activity, they have the potential to be more effective than tamoxifen.
Pretreatment of cells with actinomycin D or cycloheximide blocked the synthesis of new alpha(2 MSR.
We separated the primary photoinactivation of PSII from the counteracting repair using lincomycin, an inhibitor of 16S ribosomal function, to block the synthesis of the D1 protein, thus preventing any PSII repair (Fig. 1).
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