Sentence examples for blocking the phosphorylation of from inspiring English sources

This inhibition occurs at least in part via blocking the phosphorylation of CDK9, a p-TEFb complex member that serves as a cofactor for Tat-mediated transcription.

However, Wang et al. showed that protective effects of octacosanol against Parkinson might be mediated by blocking the phosphorylation of p38MAPK and JNK on the signal transduction24, more work needs to be done to understand its mechanism of action.

This led to an enhanced TGF-β1 response and interfered with the ability of AZD8055 to inhibit TGF-β1 induced collagen synthesis (Fig. 6a, b) indicating that the inhibitory effects of AZD8055 are mediated by blocking the phosphorylation of 4E-BP1.

This interaction inhibits the kinase activity of mTOR, thereby blocking the phosphorylation of effector molecules, including p70 S6 kinase (p70S6K) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) [5].

Smad7 is a member of the I-Smad subfamily that is able to directly interact with the TGF-β type I receptor [7], whereas blocking the phosphorylation of R-Smads Smad2 and Smad3 and inhibiting TGF-β signaling.

Blocking the phosphorylation of PDE4s by PKA catalytic subunit takes the model out of its original equilibrium and therefore, before applying the stimulation, the ten min of simulation time allows the system to re-equilibrate, analogous to the application of H89 ten min prior to imaging as performed by Terrin et al. [16].

Moreover, compounds 8k and 8l almost completely blocked the phosphorylation of EGFR in A431 cell line at 0.01 μM.

Among them, compound 10b displayed the strongest inhibitory potency to block the phosphorylation of the EGFR T790M enzyme, with an IC50 value of 4.3 nM.

Pretreatment of cells with the pan-caspase inhibitor Z-VAD-FMK blocked the phosphorylation of histone 2AX and cleavage of PARP-1 and caspases.

Compounds 8l, 9n, 9o, 9q and 9v almost completely blocked the phosphorylation of EGFR in the A431 cell line at 1 μM.

On the other hand, Plk1 inhibitors reduce or block the phosphorylation of several proteasome subunits (Grosstessner-Hain et al., 2011; Kettenbach et al., 2011; Santamaria et al., 2011).