Sentence examples for blocking the internalization of from inspiring English sources
We have now shown that blocking the internalization of the CysLT1R does not reduce this phosphorylation but, instead, a slight increase of the signal is detected (Fig. 9A).
Various antibodies targeting TfR have shown different modes of action in different models, including blocking of transferrin binding to the receptor [ 40], blocking the internalization of the TfR-transferrin complex [ 41], downregulating cell-surface TfR [ 42], or causing intracellular degradation of TfR [ 43].
This was further proven by the results that the inhibition of phagocytosis did not block the internalization of QDs into protozoans.
The depletion of FLNa by siRNA blocked the internalization of CCR2B even at 30 min after ligand stimulation (compare Figure 8 Ai to Aii).
To examine the role of activity-dependent endocytosis of A-type channels in intrinsic plasticity, we blocked the internalization of A-type K+ channels by including a dynamin-based peptide (DYN, 100 µg/ml) in the patch pipette before applying paired conditioning stimulation (Figure 5 and 6).
Dyngo treatment blocked the internalization of TfR.
The antibody thus appears to block the internalization of exogenous ATXN1 oligomers rather than interacting directly with intracellular oligomeric species.
Similarly, treatment of cells with Dyngo seemed to completely block the internalization of endogenous ABCB6, as ABCB6 remained on the surface throughout the entire 30-min time course.
Furthermore, the Cat1-a mutation notably blocked the internalization of Cat1-EGFP by the cycloheximide treatment, similar to that observed in arn1Δ (Fig. 3E, Fig. 8D).
In contrast, Arf6 Q67L overexpression was found to completely block the internalization of MHC class I molecules ([11] and data not shown).
In OSCC, the anti-TFRC antibody is suspected to block the internalization of transferrin into cancer cells, and the resulting transferrin deficiency might block the cell cycle and/or induce apoptotic cell death due to the potentially abnormal transferrin requirements of cancer cells 21.
