Sentence examples for blocking the interactions with from inspiring English sources

Antiviral therapies targeted at CD4 can potentially have an undesired immunomodulatory effect, by either signaling through CD4 or blocking the interactions with MHC class II.

The transcription repression of the kinase module is independent of the kinase activity of Cdk8 and is likely related to blocking the interactions with RNAPII.

The CD28 aptamers described in this work could be used to modulate the immune response either blocking the interaction with B7 or enhancing vaccine-induced immune responses in cancer immunotherapy.

Natalizumab is a monoclonal antibody against α4-integrin, blocking the interaction with its ligands.

It does so by binding to their shared p40 subunit, therefore blocking the interaction with their cognate receptors.

Bad phosphorylation causes inactivation of its pro-apoptotic properties by blocking the interaction with Bcl-XL, [ 44, 51].

ABT, a CTLA-4-immunoglobulin-fusion protein, inhibits T cell activation by binding to CD80 and CD86, thus blocking the interaction with CD28 [ 4].

The major basic protein from eosinophils can bind directly to M2 receptors, blocking the interaction with acetylcholine that leads to a higher release of acetylcholine in airway smooth muscles [ 10].

These findings have important implications for exploiting the properties of mincle in developing potential ways of blocking the interaction with mycobacterial ligands during human infections with Mycobacterium tuberculosis as well as agriculturally important infections of cows with M. bovis, since approaches that are developed for either protein will also be applicable to the other.

Furthermore, heparin completely blocked the interaction with LPS as well as antimicrobial activity, confirming that heparin interacting sequences of PrP mediate LPS binding, and thus, antimicrobial activity (not shown).

The BCL-2 family binders block the interaction with their natural interaction partner and will be valuable reagents to test the apoptotic response in functional assays.