Assuming they utilize the same protein complex as vaccinia, he says, researchers may be able to fight these infections by blocking the interaction of the two proteins.
Here four target compounds were designed and synthesized to bind to TAR RNA for blocking the interaction of Tat TAR RNA.
We tested C-82, a therapeutic that inhibits canonical Wnt signaling by blocking the interaction of the protein CBP with β-Catenin and inhibiting Wnt-activated genes.
Our findings collectively demonstrate that M2-2 uses its PDZ motifs to launch the hMPV immune evasion through blocking the interaction of MAVS and its downstream TRAFs.
In this context, neither N-6 nor UVI3003 was able to inhibit the induced transactivation (Fig. 3F), which also demonstrated the inability of N-6 and UVI3003 for blocking the interaction of TR3 and RXRα.
ANG2 is produced by endothelial cells in hypoxic environments and would typically recruit pro-angiogenic cells, however binding of ANG2 with a monoclonal antibody inhibited angiogenesis by blocking the interaction of ANG2 with TIE2-expressing monocytes [44],[44].
Especially, WL-15 was one of the most potent inhibitors, blocking the interaction of MLL1 WDR5 with IC50 value of 26.4 nM in competitive binding assay and inhibiting the catalytic activity of MLL1 complex with IC50 value of 5.4 μM.
In conclusion, our study provides a proof of concept that blocking the interaction of p110α with p85 by a peptide can serve as a new strategy to inhibit the oncogenic activity of PI3K in cancer therapy.
