Sentence examples for blocking the interaction in from inspiring English sources

Furthermore, we have shown that blocking the interaction in this way reduces PCSK9-mediated LDLR degradation in a hepatocyte cell-based system.

It is very important to explore the interaction between S100B and p53 and to develop inhibitors to block the interaction in anti-cancer development.

The detailed consequences of blocking the interaction between CD80/86 and CD28 in RA still require study, in particular because co-stimulatory pathways other than CD28-mediated ones remain unaffected.

Blocking the interaction of S100A12 and RAGE results in improvement of inflammation in multiple experimental models [ 18, 19].

Furthermore, the monomeric circular peptide C-RLKEKH-C, was effective in blocking the interaction between 125I-fibrinogen and Mac-1 (IC50 = 3.35 ± 0.1 × 10− 6 M), and inhibited the adhesion of human neutrophils to fibrinogen and iC3b.

Peptides have been effective in blocking the interaction between the SARS coronavirus and cellular protein angiotensin-converting enzyme 2, the first step in viral infection (19).

Abatacept is thought to block costimulation of T cells by blocking the interaction between CD28 and B7, resulting in inhibition of T cell activation.

In these instances blocking the interaction between p53 and HDM2 is hypothesized to stabilize p53 leading to pathway activation and growth arrest and/or apoptosis in cancer.

In the mouse model of neonatal HI, Necrostatin-1 blocked the interaction of RIPK1 and RIPK3 in the neurons.

The failure of the cAMP analogue to block the interaction of glucokinase with PFK2/FBPase2 in the BiFC assay indicates that phosphorylation does not prevent formation of the complex.

Treatment of the cells with arginine-glycine-aspartic acid (RGD) peptides that block the interactions between integrins, in particular α5β1, and their ligands (Hynes, 2002), almost completely prevented the adhesion of ASM-treated tumor cells to fibronectin-coated cover slips (Fig 5D).