Sentence examples for blocking the fusion of from inspiring English sources

Intriguingly, PLP2-TM induces incomplete autophagy process by increasing the accumulation of autophagosomes but blocking the fusion of autophagosomes with lysosomes.

Bafilomycin A1 specifically inhibits AVO formation by blocking the fusion of autophagosomes and lysosomes (Yamamoto et al, 1998).

LY294002 is a known phosphatidylinositol 3-kinase (PI3K) inhibitor that blocks endocytosis by blocking the fusion of clathrin or nonclathrin vesicles with early endosomes (Naslavsky et al., 2003).

Manzamine A could block the fusion of autophagosome and lysosome and abrogate autophagosome turnover [ 13].

Bafilomycin (BAF) is widely used to block the fusion of autophagosomes with lysosomes, resulting in accumulation of autophagosomes in the cytoplasm.

Bafilomycin A1, a type of macrolide antibiotic derived from Streptomyces griseus, has been reported to block the fusion of autophagosomes with lysosomes in tumor cells.

To obtain more quantitative assessment of the induction of autophagy, we used bafilomycin-A1 (Baf-A1; 10 nM) to block the fusion of autophagosomes and lysosomes and assess the presence of autophagy flux.

To ensure that this is a dynamic and complete autophagic process and not just the accumulation of endocytosed oxLDL in autophagic vesicles, we blocked the fusion of the autophagosome with the lysosome using bafilomycin A1.

The cells undergo apoptosis when beclin-1, ATG, or PI3K is inactivated to block the autophagy at an early stage, or when the lysosomal protein LAMP2 is depleted to block the fusion of autophagosomes and lysosomes at the late stage [ 5].

To better interpret changes in LC3, chloroquine was used to block the fusion of the autophagosome with the lysosome, and Figures 5g−i show that pretreatment with chloroquine could upregulate LC3 and p62 significantly for 3 h after β1-AABs stimulation, indicating that early increases in LC3 offer efficient autophagic flux.

The prM protein is thought to protect the immature virion from undergoing premature fusion prior to viral budding from the cell surface by blocking the fusion loop of E and is cleaved off during the viral maturation process [ 32– 32].