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Future studies will define the pathways for HMGB1 release in disease, elucidate the most effective strategies for blocking the effect of this mediator, and determine the nature of any side effects that develop when levels of HMGB1 are reduced.
They also tried blocking the effect of brain chemicals they thought might be involved in the positive state, like dopamine.
Blocking the effect of adrenalin with the high blood pressure medicine prazosin breaks the cycle.
First developed in the 1960s, naloxone binds to the brain's opioid receptors, blocking the effect of oxycodone or heroin, and sends the body into immediate withdrawal.
For example, drugs blocking the effect of T in some animal studies can decrease sexual interest, but social pressure moderates the link.
We can block opioid receptors with selective drugs that subsequently block the development of conditioned place and partner preferences, essentially blocking the effect of sexual reward.
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Naltrexone is a competitive antagonist for opioid receptors, effectively blocking the effects of endorphins and opiates.
Thus, blocking the effects of pro-inflammatory mediators could be an effective therapeutic strategy.
It works by blocking the effects of estrogen, which can spur the growth of some breast tumors.
Blocking the effects of adrenalin with a beta-blocker also impairs the emotional memory (I've even done experiments of this sort myself).
"Caffeine keeps you operating at a high level by blocking the effects of adenosine, a sleep-inducing brain chemical that accumulates as the day wears on," Ms. Eller writes.
More suggestions(18)
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