Sentence examples for blocking the decrease in from inspiring English sources

Thus, knockdown of Myc prevents CMS sensitization to TRAIL by blocking the decrease in FLIPL levels, which ultimately inhibits generation of active p18 caspase-8.

Pro-survival Bcl-2 family members act by keeping death-inducing Bcl-2 proteins in an inactive state, thereby blocking the decrease in mitochondrial membrane potential and inhibiting the activation of the apoptotic cascade.

In the present study, the less selective (JNJ-39928122 and JNJ-40529749) A2A vs. A1 antagonists potently blocked the decrease in blood pressure, whereas the more selective (JNJ-40064440 and JNJ-41501798) antagonistsists were less potent, and only effective at 10 mg/kg.

Additionally, Mf-1 partially blocked the decrease in H3K9 methylation and increases in H3K4 and H3K27 methylation.

It was observed that knocking down HIF-1α or HIF-2α alone failed to block the decrease in c-Myc protein levels initiated by Ni ions or to hypoxia; c-Myc protein degradation ceased only when both HIF-1α and HIF-2α were removed.

Histamine also blocked the decrease in heart weight, whereas it enhanced thiol levels in doxorubicin-treated animals.

The application of survival stimuli such as interleukin-4 blocked the decrease in Mcl-1 expression [ 50].

Notably, the expression of the DARPP-32 T153A mutant blocked the decrease in c-fos expression by restoring CREB phosphorylation (Fig. 5A, B, D, E).

We found that the luminescence intensity was significantly reduced by transfection of the entire 3′-UTR of PPP1CA, whereas deletion of positions 237 243 blocked the decrease in luminescence.

In mERhigh cells H-89 blocked the decrease in cell number caused by 10 nmol/l E2, and in mERlow cells it further enhanced the already existing stimulation of proliferation.

We found that the luminescence intensity was significantly reduced by transfection of the wild type 3′-UTR of HDAC1 while deletion of positions 149 155 blocked the decrease in luminescence (P<0.01, Figure 5C).