Sentence examples for blocking the cleavage of from inspiring English sources
However, the Eda peptide was found to be more effective in blocking the cleavage of proPDGF-B.
These results suggest that strategies for blocking the cleavage of the adhesion receptors on the tumor cell surface can significantly prevent cancer induced bone pain and slow disease progression within the bone.
Oncogenic BRAF V600 point mutations disrupt the restriction site, thereby blocking the cleavage of the amplification product.
However, blocking the cleavage of FasL in B6129 ΔCS mice increased apoptotic photoreceptor death, but had no effect on necrotic cell death.
Another approach has used the licensed HIV protease inhibitors nelfinavir and ritonavir, which in addition to blocking the cleavage of HIV propeptides have direct antiapoptotic effects (31 ).
Other mechanisms of cytotoxicity, including activation of antibody-dependent cell-mediated cytotoxicity (ADCC) [ 8] or blocking the cleavage of HER2 extracellular domain [ 9] have also been described.
Our results showed that treatment of cells with caspase inhibitors (Ac-DEVD-CHO, Z-VAD-FMK and Z-DEVD-FMK, 50 M) at high dose partially blocked the cleavage of GRP94 during honokiol-induced apoptosis (Fig. 8A) as compared with calpain inhibitor ALLM 25 M, which could completely block GRP94 cleavage.
Because of this the product itself can bind tightly to the active site without being further processed and thereby block the cleavage of further substrates (product inhibition).
Moreover, as shown in Figure 4B, NAC could completely block the cleavage of PARP, caspase 9, and caspase 3 in H1299 cells treated with celastrol.
Special inhibitors of PI3K may impair VM formation and decrease MT1-MMP and MMP-2 activity; inhibition of PI3K blocked the cleavage of Ln-5γ2 chain, resulting in decreased levels of the γ2, and γ2× promigratory fragments [ 49].
zVAD-fmk almost completely blocked the cleavage of ZO-1, but not the cleavage of E-cadherin, suggesting that some other proteases besides caspases can cleave it, most likely the extracellular matrix metaloprotease (MMPs).
