Sentence examples for blocking the biosynthesis of from inspiring English sources
Statin drugs moderate blood cholesterol levels by acting as competitive inhibitors for this enzyme, blocking the biosynthesis of cholesterol early in the synthesis pathway.
Inhibition of S. aureus diapophytoene desaturase (CrtN) could serve as an alternative approach for addressing the tricky antibiotic resistance by blocking the biosynthesis of carotenoid pigment which shields the bacterium from host oxidant killing.
Blocking the biosynthesis of glycans using chemical inhibitors has been shown to change the phenotype of breast cancer cells in culture, making them less aggressive [ 87, 88].
Conversely, tuning down, or blocking the biosynthesis of competing storage carbons (like that of starch in Chlamydomonas[ 20, 124, 125]) may also increase the accumulation of liquid hydrocarbons.
Glyphosate inhibits a key enzyme, EPSPS, in the shikimate pathway blocking the biosynthesis of several important amino acids and ultimately leads to plant death [ 16, 17].
Bisquaternary ammonium salts that mimic the structure of the phospholipid precursor choline have been shown to target membrane biogenesis in P. falciparum by blocking the biosynthesis of PC.
For this, we blocked the biosynthesis of new proteins with cycloheximide (CHX) and then treated Granta519 cells with WIN55,212-2.
It is reasonable that excessive mutation of structural genes would likely block the biosynthesis of anthocyanins, reducing the fitness of the plant.
In 1998, McMurry, Oethinger and Levy [ 27] suggested for the first time that TCL blocked the biosynthesis of fatty acids by inhibiting the enoyl reductase (ENR) or InhA.
Usually, the amounts are highly regulated; however, by inhibiting ceramide synthase, fumonisins block the biosynthesis of complex sphingolipids and cause sphinganine (and sometimes sphingosine) to accumulate.
Recently, nonsteroidal AIs (for example, letrozole, anastrozole) that block the biosynthesis of estrogens have proven more effective than the selective estrogen receptor modulator tamoxifen (Tam) in the treatment of postmenopausal patients with ER+ breast cancer [ 1].
