Soluble Fas (sFas) can bind to membrane-bound FasL, thus blocking the binding of the ligand to the Fas receptor, preventing apoptosis induction in the target cell, and enhancing the immunosuppressive effects of tumors.
They exert their action by blocking the binding of AngII on the AT1 receptor.
Thus, we concluded that both compounds inhibit the sulfur transfer reaction from the persulfurated intermediate by blocking the binding of the sulfur acceptor to 3MST (Fig. 4c).
Blocking the binding of VCAM to α4β1 is thought to be a way of controlling a number of disease processes.
The data suggested the potential role of P2 and P3 peptides in successfully blocking the binding of AAF-II EAEC with HEp-2 cell receptors.
Our results also indicate that the nitrogen-containing bisphosphonate drugs are potential inhibitors of FPPs and other trans-prenyltransferases aiming at blocking the binding of FPP.
Blocking the binding of TNF-α to TNF receptor subtype-1 (TNFR1) is an important strategy for the treatment of rheumatoid arthritis (RA).
It is thus likely that the repebody suppresses the hC5a-mediated immune response in monocytes by blocking the binding of hC5a to its receptor.
Symptoms of Alzheimer disease can be reduced in some patients by the drug memantine, which decreases abnormal brain activity by blocking the binding of glutamate (an excitatory neurotransmitter) to certain receptors in the brain.
These oligonucleotides synthesized for activating RNase H or blocking the binding of the translation machinery were able to reduce significantly cAanat transcription and melatonin secretion, whereas control inverted oligonucleotides were ineffective.
These results suggest that the conjugate can enter the nucleus, bind to its target site, presumably as a stacked dimer, and up-regulate the expression of topoIIα by blocking the binding of NF-Y.
