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PC10 neutralized PEDV infection through interfering with the viral life stages after cellular attachment instead of blocking the attachment of PEDV to cells.
Most notably, these specific interference mechanisms might include blocking the attachment of G. vaginalis by disturbing the pilus-mediated adhesion of the pathogen.
Addition of an anti-laminin antibody reduces significantly the formation of capillary-like structures, probably by blocking the attachment of BAE cells to laminin present in Matrigel.
Because the transport of organelles is mediated by myosin, overexpression of other F-actin-binding proteins is expected to interfere with cytoplasmic streaming by blocking the attachment of myosin to actin filaments.
Lactobacilli can also adhere onto vaginal epithelial cells [ 37] thus blocking the attachment of any pathogenic BV-associated bacteria onto these cells, Lactobacilli are known to produce biosurfactant, bacteriocins and coaggregation molecules [ 38], all of which contribute to the maintenance of a healthy vaginal micro-environment.
Lactobacilli have been proven to be effective in inhibiting enteropathogenic infections [ 3, 4] partly by competition with enteric pathogens for enterocyte binding sites, subsequently blocking the attachment of pathogens to IECs [ 5]. Cell surface properties, such as hydrophobicity and aggregation (autoaggregation and coaggregation), are necessary for the adhesion of probiotics.
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These results revealed that compound directly blocked the attachment of EV71 virion to host cell (Fig. 6).
In 2005, a study led by researchers at the University of California, Los Angeles, showed that a class of drugs called farnesyltransferase inhibitors (FTIs), which block the attachment of a molecule to the faulty protein that allows it to accumulate around the nucleus, restored normal shape to cells from kids with progeria.
Finally, a hemagglutination inhibition assay (HAI) was performed to investigate if the Infl-C8 constructs sterically blocked the attachment of Influenza H5N1 virus, NIBRG-14, to chicken erythrocytes (RBC).
Such binding may block the attachment of elongation factor G and thereby prevent the translocation of peptidyl-tRNAs from the ribosomal A-site to the P-site.
Data suggested QADMA blocked the attachment of Escherichia coli; whether this was related to the killing of microorganisms is less clear.
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