Sentence examples for blocking the association of from inspiring English sources

In more detail, following n-3 PUFA-stimulated internalization of the GPR120/ β-arrestin2 complex, β-arrestin2 associates with TAK1 binding protein 1 (TAblockingcking the association of TAB1 with activated kinase 1 (TAK1), which dampens downstream signaling to the IKK β/NF- κB and JNK/AP1 system [ 59].

Such CAR-RIAD T cells showed enhanced antitumor activity in vitro and showed more efficient migration to tumor sites in vivo by blocking the association of PKA with ezrin to blunt the inhibition of PKA on TCR activation.

Thus, C/EBPalpha inhibited cdk2 activity by blocking the association of cdk2 with cyclins to bring about growth arrest.

Our lead compound significantly inhibited ERα transcriptional activity by blocking the association of coactivators at the AF2 site.

Suramin disrupts GPCR binding with the G protein by blocking the association of G protein α and βγ subunits [ 28].

Previously, it has been shown that it is possible to inhibit ERα transcriptional activity by blocking the association of coactivators at the AF2 site.

In addition to the analysis of mutations that would block the longitudinal protofilament interfaces, we tested a number of mutations on the sides of the subunits, hoping to find ones that might block the association of protofilaments into bundles.

Although we cannot exclude the possibility that DAZL can block the association of miRNA with target mRNAs, the induction of polyadenylation by DAZL strongly suggests that DAZL relieves miRNA-mediated repression in a distinct mode from DND.

AbSV cyclic and AbHV2 cyclic, but not AbSV linear or AbHV2 linear agglutinated homologous Opa variants, and AbHV2BD cyclic but not AbHV2BD linear blocked the association of OpaB variants with human endocervical cells.

There are two reagents, novobiocin (NB) and GM, that by binding to the C-terminal domain and N-terminal ATP/ADP pockets of Hsp90, respectively, block the association of Hsp90 with its client proteins (Chiosis et al, 2004).

Interestingly, one group [ 49] has reported that their unbiased sequence interrogation of the genuine chromatin binding sites suggests that direct ER binding requires the presence of foxa1 binding in close proximity, as knockdown of FoxA1 expression blocked the association of ER with the chromatin and estrogen induced gene expression.