The rice DELLA protein is stable in the absence of GA ensuring that transcription of GA-early responsive genes are repressed by blocking the activity of a transcriptional activator bound to the promoters of target genes.
It is also currently unclear whether the anti-inflammatory effects of these small molecule kinase inhibitors result exclusively from inhibition of ZAK or from blocking the activity of other kinases that activate the inflammatory cascade in response to doxorubicin.
In fact EGCG, vitamin C and selenium inhibited the activation of NF-κB by blocking the activity of IKK [ 23, 24].
The available literature suggests that ibuprofen inhibits the activation of NF-κB by blocking the activity of phosphorylating kinases IκB [ 32].
Rac1 via activation of the p21-activated kinase (PAK) antagonizes this process by blocking the activity of myosin light chain kinase.
Furthermore, Zhang et al. found that blocking the activity of the GPCRs with a drug can activate autophagy and reduce the amount of misfolded proteins in the cell.
Genetic silencing of Slc25a1 or inhibition of fatty acid synthesis by blocking the activity of ACC both result in the impairment of LPS-induced DC activation.
Vismodegib works by blocking the activity of a biological signaling cascade called the Hedgehog pathway.
Conversely, blocking the activity of NKX3-1 prevents any reprogramming by the Yamanaka factors.
Click image to see the pink loop where copper binds, blocking the activity of the enzyme.
Because it has two non-overlapping inhibitory sites, EnStef is capable of simultaneously blocking the activity of both the papain-like cysteine peptidases and asparaginyl endopeptidases.
