Sentence examples for blocking the accessibility of from inspiring English sources

Another example comes from the two overlapping isoforms of the human c-erbAlpha gene where natural anti-sense transcripts inhibit the alternate splicing of mRNA, probably by blocking the accessibility of cis regulatory elements [37].

These elements provide an explanation for the decreased binding of IFNγ to LcrV in the presence of IFNγR: titration of IFNγ by its receptor causes steric hindrance for LcrV recognition, thus blocking the accessibility of the IFNγ C-terminus for interaction with LcrV.

If so, an increased affinity between Alp14 and Alp7 in the nucleus might be able to inhibit nuclear export of the Alp7 Alp14 complex by blocking the accessibility of Crm1.

The oily contamination layer is, thus, only suggested to block the accessibility of aqueous plating solution onto the substrate surface, thereby hindering the coating nucleation at the areas of poor cleaning.

Besides, the linker region can prevent steric hindrance that would block the accessibility of the reactive group or of the tags used for purification.

Whether TrAP might alter KYP conformation or block the accessibility of substrates to the active sites upon interaction awaits future structural analysis.

One possibility is that the stable binding of Ubr2 to Tex19.1 blocks the accessibility of Tex19.1 by other E3 ligases.

TgICMAP1 is likely to have a high affinity for MTs, as heavy eGFP-TgICMAP1 coating correlated with much weaker anti-tubulin staining when compared with that of uncoated MT segments, suggesting that perhaps TgICMAP1 binding blocks the accessibility of tubulin antibody to the MTs (Figure 2, insets).

Second, although residue Phe itself is not part of the epitope, F198S mutation may affect the disulfide bond between residues 179 and 214, which blocks the accessibility of the V14 epitope.

We have demonstrated previously that reduction and alkylation blocks the accessibility of the 6H4 epitope but not epitopes of 3F4 and anti-C by breaking the disulfide bond of PrP [ 13].

Thus, if every residue in a biclique pattern has a small solvent accessible surface area (SASA) in the complex, then this biclique pattern reflects best the spirit of 'double water exclusion' all the inner hot residues are organized as a biclique without holding any water molecule, while there exist a ring of residues blocking the solvent accessibility to the hot spot.