Next, we investigated whether compounds APS, 3∗43, 3∗20 and 5∗362 were able to block replication of an SGR that was resistant to one of the DAAs in current use.
Punicalagin is the most effective anti-influenza component in this extract, blocking replication of influenza virus RNA and inhibiting agglutination of chicken red blood cells by the virus [ 156, 157].
To identify inhibitor candidates, we have analyzed hit compounds that emerged from a large-scale high-throughput screen for their ability to block replication of members of both the orthomyxovirus and paramyxovirus families.
Another new group of drugs to emerge, the 3C protease inhibitors, are designed to block replication of rhinoviruses once they've penetrated your nasal cells.
Thirteen siRNAs targeting conserved regions of the virus could effectively block replication of CA16 in cultured cells.
This agent, which is in phase 2 clinical trials, is delivered to hepatocytes to block replication of hepatitis C viruses [ 71].
These observations are in agreement with the biological effect of SHPR142 and SHPR190 which are able to block replication of HIV-1 in primary lymphocytes or macrophages when added to the culture medium [ 14].
These biochemical results help us understand the possible role of Srs2 in the processing of stalled or blocked replication forks as a part of post-replication repair as well as homologous recombination (HR).
At various points during infection we added a potent DNA gyrase inhibitor (ciprofloxacin) that blocks replication of DNA in a broad spectrum of bacteria, plasmids and phage (Alonso et al., 1981; Constantinou et al., 1986; Fisher et al., 1989).
Unrepaired UV-induced damage has been demonstrated to block replication forks, and replication of such damaged templates promotes sister-chromatid recombination (Branzei and Foiani 2010).
