Sentence examples for blocking phosphorylation of the from inspiring English sources

Luteolin, inhibitor of cyclin-dependent kinase 9 (can9), can induce apoptosis in cancer cells through blocking phosphorylation of the carboxy-terminal domain of RNA polymerase II [ 23].

Reciprocally, blocking phosphorylation of the MAPK sites by changing these residues to Alanine (A) (GroAA) leads to the overpotentiation of Gro's corepressor capacity (Hasson et al, 2005).

Although blocking phosphorylation of the targets downstream of mTORC1 (such as p-S6, p-IRS1-S636/639), rapamycin did not affect phosphorylation of AKT at either S473 or T308.

In addition, m-TOR drugs may attenuate the angiotensin II-induced increase in protein synthesis by blocking phosphorylation of the p-70 ribosomal S6 protein involved in cardiac growth [ 20, 22].

In prostate cancer, for example, ELF5 has been shown to inhibit transforming growth factor (TGF -β-driven epiTGF -β-drivenchymal TGF -β-driven blocking phosphorylation of thepithelial mesenchymalin SMAD3 [ 17].

Ponatinib strongly blocked phosphorylation of the generic substrate myelin basic protein (MBP), indicating inhibitory activity on both kinases.

KU55933 blocked phosphorylation of the ATM target protein Chk2 (Fig 3D) and impaired senescence in drug-treated melanoma cells (Fig 3E), suggesting that ATM/Chk2 mediates drug-induced senescence.

PPP did not compete with ATP but interfered with phosphorylation in the activation loop of the kinase domain, in which it specifically blocked phosphorylation of the tyrosine (Y) 1136 residue, while sparing the two others (Y1131 and Y1135).

Furthermore, intracellular signalling is compartmentalized by spatial restriction mechanisms such as immobilization in lipid rafts [ 50, 51] or attachment to scaffold proteins [ 52, 53], and RGS2 could block phosphorylation of the GPCR signalling-associated p44/42 MAPK pool without affecting other pools.

In summary, blocking phosphorylation of C/EBPβ-Thr217 through the inhibition of RSK activity with the C/EBPβ-Ala217 transgene or by C/EBPβ gene knock-out decreases the fibrotic response of the liver to chronic injury.

Chk1 phosphorylates Cdc2 at Y15, blocking phosphorylation of histone H3 and arresting the cell cycle at G2/M and S phase as well as allowing cells to undergo HDR-mediated DNA repair.