Sentence examples for blocking of the interaction from inspiring English sources

However, the weight of evidence from mutational analysis, the yeast data described below and the AON titrations strongly suggest that the inhibitory effect of AONs directed against motif 1 are likely due to their blocking of the interaction between mRNA and 18S rRNA.

Two main mechanisms have been proposed to contribute to this inhibitory effect; 1) the down-modulation of lipid raft formation through modulation of Rho GTPase activity and 2) the blocking of the interaction between virion-associated ICAM-1 and cell associated LFA-1 [3], [3].

When the specific antibodies for α 6 and β1 were added to the culture system, effective blocking of the interaction of HAb18G/CD147 and integrin α6β1 reduced cell invasion and MMP secretion.

The efficacy of non-depleting anti-CD4 antibodies is thought to be mediated by down-modulation of the CD4 receptor on T cells through internalization of the antibody-receptor complex and subsequent blocking of the interaction of the remaining CD4 co-receptor with MHCII on antigen presenting cells, resulting in reduced T cell activation.

It is shown that the presence of pH buffer can lead to complete blocking of the interactions in such complexes and the resulting microgel contraction/swelling response.

Via neutrophil CD11b/CD18 and endothelial ICAM-1 interactions, neutrophils adhere to activated vascular endothelium and infiltrate into the injured area, and blocking of the interactions would result in reduced leukocyte accumulation [ 39, 40].

CD40L has been implicated as a cofactor or even the cause of TRALI [ 1]. (1) We hypothesized that blocking of the CD40-CD40L interaction protects against lung injury in a murine model of TRALI.

Fascinatingly, blocking of the Fas-FasL interaction in TC cells impairs apoptosis induction by Nutlin-3 as well as combined treatment with Nutlin-3 and cisplatin.

We show that blocking of these interactions interferes with the clustering behavior, both in vitro and in vivo.

It is also noteworthy that the analysis of gender errors showed that the emerging benefit of Rhyme&Melody over Prose was temporally correlated with the emerging benefit of blocking and the interaction of blocking and Rhyme&Melody, so clearly it was the combination of input optimization techniques that did the trick.

To test this possibility and to ascertain how autocrine signaling might influence SCG neuron development, we studied the effects of blocking the interaction of CD40L and CD40 using function-blocking antibodies and quantified neuronal survival and neurite growth.