Sentence examples for blocking of the integrin from inspiring English sources

Furthermore, blocking of the integrin αVβ3 signaling pathway has been shown to increase bone mineral density in women with postmenoposal osteoporosis [ 20].

Our data show that reduced production of endogenous type IV collagen, blocking of the CB3-region on the type IV collagen molecule and blocking of the integrin β1 receptor, all lead to a pronounced growth inhibition.

Thirdly, the combined effect of removal of sialic acid residues and blocking of the integrin receptor displays a synergistic pattern, which is possibly resulting from less initial binding and followed by preventing protein interaction with the ECM.

Based on our own blocking studies, increased α2 seems more likely connected with elevated motile behaviour, because functional blocking of the integrin α2 subunit distinctly inhibited both chemotactic movement and migration through a collagen matrix.

The synergistic effect of sialic acid removal and function blocking antibody use, may result from less initial interaction and is probably followed by a better function blocking of the integrin receptor, which may result from less sterical hindrance of the antibody recognition.

Other significant findings are the differences between the effect of sialidase treatment or blocking of the α2β1 integrin receptor and the synergistic effect of sialidase treatment and the integrin receptor blocking in C4-2B cells.

Furthermore, function blocking of the α2β1 integrin receptor in C4-2B cells was found to significantly block the adhesion, whereas no such effect was observed in the LNCaP cells in the present test conditions, which corresponds to our previously published data after 90 min incubation [ 18].

In our previous study, we reported that function blocking of this integrin receptor and GSL did not result in any additional diminished adhesion to collagen type I after 90 min incubation, and also in the present study, no synergistic effect was observed by the co-antibody treatment of LNCaP and C4-2B cells, nor after sialidase treatment (results not shown).

When the specific antibodies for α 6 and β1 were added to the culture system, effective blocking of the interaction of HAb18G/CD147 and integrin α6β1 reduced cell invasion and MMP secretion.

It is likely that the split seen in normal HSEs is due to the blocking of β4 integrin by ASC-8.

The blocking of β7-integrins in the cervical tissue also decreased infection in the emigrating DCs by 49% (p = 0.012) for F-HIV and 66% (p = 0.001) for C-HIV (Fig. 5G).