Sentence examples for blocking of cell death from inspiring English sources

As an example for medical application we investigated the blocking of cell death by viral interference.

The authors demonstrated that suppression of "fatty acid desaturase 1" caused blocking of cell death induced by Bcl2-associated X (Bax) protein in tabacco plants [ 24].

Cotreatment with the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) or panobinostat (LBH589) and the BRAF inhibitor PLX4720 activated the caspase cascade, but caspases appeared dispensable for killing, in that inhibition of caspases did not invariably block induction of cell death.

These two ectopic neuroblast lineages are also observed following MARCM-based block of cell death and, significantly, these ectopic lineages are Labial-positive.

A nearly complete block of cell death by either pan-caspase (z-Val-Ala-Asp-fluoromethylketone (zVADfmk)) or caspase-3 selective (z-Asp-Glu-Val-Asp-fluoromethylketone (zDEVDfmk)) inhibitors and failure of necrostatin-1 to prevent or reduce cell death (data not shown) indicated that Huh-7 and Colo205 undergo predominantly apoptotic cell death upon treatment with scTRAIL fusion proteins.

Because of this, blocking one pathway of cell death may not prevent the final outcome of cell loss, as other simultaneously induced pathways may take over the executioner's role.

In contrast, the neutralizing anti-Fas antibody completely blocked the activation of cell death as mediated by cytotoxic anti-Fas CH11 antibodies (Figure 2A).

More important, pretreatment with Abs specific for Fas significantly blocked the potentiation of cell death by TNF-α stimulation measured by MTT (Figure 5B), and LDH release (Figure 5C).

The consequence of persistent c-FLIP expression is the suppression of apoptosis, as c-FLIP inhibits caspase-8 to block the progression of cell death.

As BCLAF1 displaces Beclin-1 from BCL-2 to promote autophagic cell death, this caspase-10/FLIPL complex blocks this mode of cell death.

As shown in Figure 1h, while 3  μM of FAD on its own can induce a significant level of autophagy as shown by increased GFP-LC3 foci formation and a low level of cell death, blocking autophagy with chloroquine exacerbated FAD-induced cell death (P<0.05, Figure 1h).