Sentence examples similar to blocking of activation from inspiring English sources

Many of the procedures are based on the blocking of complement activation at the C3 level which implies a general and broad inhibition but others are based on the selective blocking of C5 activation which leads to the inhibition of C5a and C5b-9 formation [38].

Previous biochemical work has implicated chemical inhibition of MEK and subsequent blocking of ERK1/2 activation as a major pathway responsible for cortactin S405/418 phosphorylation [40].

It has been demonstrated, for example, that blocking of complement activation protects against lung injury triggered by the administration of heterologous immune complexes.

In addition, blocking of p38 MAPK activation by SB203580 significantly inhibited generation of the active form of MMP-2.

Why is this approach preferable to direct blocking of ERK activity by MEK inhibitors, or to blocking of integrin activation by antagonists?

U0126 acts in the unique manner of blocking activation of MEK through a mechanism independent of the ATP binding site [ 12, 23].

This indicates that the outcome of CD95 ligation on naïve T cells largely depends on the "dose of agonist", resulting in opposite effects from a complete block of activation (at high doses) to prominent costimulatory activation (at lower concentrations).

These data illustrate a strategy of blocking activation of adaptive autophagy pathway to improve treatment outcomes in leukemia and MCL.

Inhibiting both targets in parallel may have the dual advantage of blocking the activation of the tumor-specific growth pathway while reducing the cancer cells' attempts to bypass the activation block.

Development of a drug blocking the activation of (P RR by renin proved to be very difficult, since structure function studies and crystallographic data are lacking.

This study provides insights for the design of new therapeutic proteins capable of blocking complement activation.