Sentence examples for blocking mTOR in the from inspiring English sources

For example, either pharmacologically [54], [55] or genetically [56] blocking mTOR in the animals impairs memory consolidation.

This study aims to discover the effects of blocking mTOR signaling in ligation-induced atrophic salivary glands.

We showed that FA blocked mTOR activity in the skin.

These results show that blocking mTOR activity mimics many of the effects of ND in the CMZ, raising the possibility that mTOR mediates the effects of ND.

Despite the highly heterogeneous response to rapamycin seen in the panel of hepatic cell lines that we studied, a uniform finding was that rapamycin was effective in blocking mTOR signaling to S6 and 4E-BP1 in all cell lines.

Indeed, blocking mTOR led to an increase in levels of phosphorylated AKT in both mutants and wild types compared with DMSO-treated controls (supplementary material Fig. S13), similar to the effects of ethanol.

Surprisingly, instead of glucose consumption being reduced, blocking mTOR led to an increase in glucose consumption and lactate production.

We then evaluated the effects of blocking mTOR with rapamycin and FST-transfection on gene expression in PI3K/Akt/mTOR signalling.

To probe the therapeutic value of targeting M-CSF, we tested whether blocking mTOR signaling (which is downstream M-CSF) would counteract the osteopenic disease in Sf mice.

Blocking mTOR in RPE cells reduces cell senescence leading to cell quiescence [19].

In the present study, we demonstrated that blocking mTOR activity might induce inhibition of cancer cell proliferation and survival.